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Synthetic biology - Latest research and news | Nature

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Synthetic biology is the design and construction of new biological parts, devices, and systems, and the re-design of existing, natural biological systems ... Skiptomaincontent Thankyouforvisitingnature.com.YouareusingabrowserversionwithlimitedsupportforCSS.Toobtain thebestexperience,werecommendyouuseamoreuptodatebrowser(orturnoffcompatibilitymodein InternetExplorer).Inthemeantime,toensurecontinuedsupport,wearedisplayingthesitewithoutstyles andJavaScript. Advertisement nature subjects syntheticbiology Atom RSSFeed Syntheticbiology Definition Syntheticbiologyisthedesignandconstructionofnewbiologicalparts,devices,andsystems,andthere-designofexisting,naturalbiologicalsystemsforusefulpurposes. Featured News&Views | 31March2022 Livingbuildingblocks KwokSoonWun,InYoungHwang & MatthewWookChang NatureMaterials21,382-383 LatestResearchandReviews Research 11April2022 | OpenAccess ReprogrammedtracrRNAsenablerepurposingofRNAsascrRNAsandsequence-specificRNAbiosensors IntypeIICRISPRsystems,theguideRNA(gRNA)comprisesaCRISPRRNA(crRNA)andahybridizedtrans-actingCRISPRRNA(tracrRNA),bothbeingessentialinguidedDNAtargetingfunctions.HeretheauthorsinvestigatetheprogrammabilityofcrRNA-tracrRNAhybridizationforCas9andapplythistobiosensing. YangLiu,FilipePinto & BaojunWang NatureCommunications13,1937 Research 07April2022 | OpenAccess AgenetictoolkitandgeneswitchestolimitMycoplasmagrowthforbiosafetyapplications Mycoplasmasareminimalcellmodelorganismsbutlackgenetictools.HeretheauthorsprovidearobustgenetictoolkitforMycoplasmademonstratinggenecircuitengineeringapplications. AliciaBroto,ErikaGaspari & MarkIsalan NatureCommunications13,1910 Protocols | 06April2022 CRISPR–Cas9-mediatedchromosomeengineeringinArabidopsisthaliana Thischromosome-engineeringprotocolgeneratesheritablechromosomalrearrangementsinA.thaliana;bycombiningSaCas9withanegg-cell-specificpromotertofacilitateheritablemutations,chromosomalrearrangementscanbemadeandhomozygouslinescanbeestablished. MichelleRönspies,PatrickSchindele & HolgerPuchta NatureProtocols,1-27 Research 06April2022 | OpenAccess Metal-responsiveregulationofenzymecatalysisusinggeneticallyencodedchemicalswitches Dynamiccontroloverproteinfunctionisacentralchallengeinsyntheticbiology.Heretheauthorspresentanintegratedcomputationalandexperimentalworkflowforengineeringreversibleproteinswitches;metal-chelatingunnaturalaminoacidsgeneticallyencodedintotwoconformationallydynamicenzymestoyieldrobustswitches. YasmineS.Zubi,KosukeSeki & JaredC.Lewis NatureCommunications13,1864 Research 05April2022 | OpenAccess Cryo-EMstructuresofaLptDEtransporterincomplexwithPro-macrobodiesofferinsightintolipopolysaccharidetranslocation LateralopeningoftheLptDEtransporterintheoutermembraneofGram-negativebacteriaisnecessaryforinsertionoflipopolysaccharides.Here,Botteetal.reportacryo-EMstructureofapartiallyopenedLptDEtransporter,incomplexwithrigidchaperonesderivedfromnanobodies. MathieuBotte,DongchunNi & MichaelHennig NatureCommunications13,1826 Research 01April2022 | OpenAccess Harnessingphosphonateantibioticsargolaphosbiosynthesisenablesasyntheticbiology-basedgreensynthesisofglyphosate Currentcommercializedproductionprocessesofglyphosatearegenerallyassociatedwithmanufacturinghazardsandtoxicwastes.Here,toaddresstheproblems,theauthorsreportthebioproductionofaminomethylphosphonate(AMP)andachemicalprocessfortheconversionofAMPtoglyphosate. LeixiaChu,XiaoxiaLuo & JiangtaoGao NatureCommunications13,1736 AllResearch&Reviews NewsandComment ResearchHighlights | 07April2022 Bacteriadeliverthegoods M.TeresaVillanueva NatureReviewsDrugDiscovery Editorial | 31March2022 Materialscomealive Thedisseminationofsyntheticbiologyintomaterialsscienceiscreatinganevolvingclassoffunctional,engineeredlivingmaterialsthatcangrow,senseandadaptsimilartobiologicalorganisms. NatureMaterials21,379 News&Views | 31March2022 Livingbuildingblocks Aprototypicalbiocompositeblockcomprisingablendofbacteria,fungiandfeedstockcanbeassembledintohuman-sized,livingstructureswithself-healingandenvironmentalsensingcapabilities. KwokSoonWun,InYoungHwang & MatthewWookChang NatureMaterials21,382-383 Correspondence | 29March2022 Makingspaceforyoungspeakers TaeSeokMoon NatureChemicalBiology18,353 ResearchHighlights | 21March2022 Neighbourlymodulationoftranscriptisoforms ApaperinSciencedescribesasysteminsyntheticyeastchromosomesinwhichthepropertiesofgeneticsequenceschangedependingontheneighbouringtranscriptionalactivity. LuciaBrunello NatureReviewsGenetics,1 News&Views | 17February2022 Logicinvadescell-freebiosensing Cell-freebiosensingisemergingasaneffectiveandlow-costtechnology,butinterpretationandsynthesisoftheresultsremainslargelymanual.Now,researchershaveincorporatedanewinformation-processinglayerbetweenbiosensorsandtheiroutputsusinglogicgatestointegratecomplexresults. EvanAmalfitano & KeithPardee NatureChemicalBiology18,356-358 AllNews&Comment Search Searcharticlesbysubject,keywordorauthor Showresultsfrom Alljournals Search Advancedsearch Quicklinks Explorearticlesbysubject Findajob Guidetoauthors Editorialpolicies

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