Epigenetic memory - Latest research and news | Nature

The epigenetic memory of a cell defines the set of modifications to the cell's deoxyribonucleic acid (DNA) that do not alter the DNA sequence, and have been ... Skiptomaincontent Thankyouforvisitingnature.com.YouareusingabrowserversionwithlimitedsupportforCSS.Toobtain thebestexperience,werecommendyouuseamoreuptodatebrowser(orturnoffcompatibilitymodein InternetExplorer).Inthemeantime,toensurecontinuedsupport,wearedisplayingthesitewithoutstyles andJavaScript. Advertisement nature subjects epigeneticmemory Atom RSSFeed Epigeneticmemory Definition Theepigeneticmemoryofacelldefinesthesetofmodificationstothecell'sdeoxyribonucleicacid(DNA)thatdonotaltertheDNAsequence,andhavebeeninheritedfromthecellfromwhichitdescends.Suchmodificationscanaltergeneexpressionandthereforethepropertiesandbehaviourofthecell. LatestResearchandReviews Research 06April2022 | OpenAccess ElasticdosagecompensationbyX-chromosomeupregulation Theconcerted dynamicsofX-chromosomeupregulationandX-chromosomeinactivation,whichcollectivelybalanceX-chromosomeexpression,arenotwellunderstood.Usingallelicsingle-cellgenomics,theauthorscharacterizethedynamicsofX-chromosomeupregulationandinactivationalongmouseembryonicandstemcelldevelopment,callingtoquestionkeysaspectsoftheestablishedmodelofmammaliandosagecompensation. AntonioLentini,HuaitaoCheng & BjörnReinius NatureCommunications13,1854 Research 14March2022 | OpenAccess Malfunctionofairwaybasalstemcellsplaysacrucialroleinpathophysiologyoftracheobronchopathiaosteoplastica Tracheobronchopathiaosteoplastica(TO),isanunderreportedafflictioncharacterizedbysquamousmetaplasiaandheterotopicboneformationintracheaandbronchi.Heretheauthorsapplyfunctional,aswellasgenome-widetranscriptionalandepigeneticprofilingtoidentifyairwaybasalcellsdysfunctionunderlyingTO. YueHong,ShanShan & TaoRen NatureCommunications13,1309 Research 04March2022 | OpenAccess Thecontroloftranscriptionalmemorybystablemitoticbookmarking Usingquantitativeimagingandmonitoringtranscriptioninlivingembryos,Bellecetal.,provideevidencethatthepioneerfactorGAFactsasastablemitoticbookmarkerduringearlyDrosophiladevelopment. MaëlleBellec,JérémyDufourt & MouniaLagha NatureCommunications13,1176 Research | 07February2022 Membrane-associatedcytoplasmicgranulescarryingtheArgonauteproteinWAGO-3enablepaternalepigeneticinheritanceinCaenorhabditiselegans Schreieretal.reportapreviouslyundescribedcytoplasmiccondensate,termedthepaternalepigeneticinheritance(PEI)granule,thatcontainstheArgonauteproteinWAGO-3and22GsmallRNAsandmediatespaternalepigeneticinheritanceinC.elegans. JanSchreier,SabrinaDietz & RenéF.Ketting NatureCellBiology24,217-229 Research 10January2022 | OpenAccess Lifelongsingle-cellprofilingofcranialneuralcrestdiversificationinzebrafish Cranialneuralcrestgeneratesawidediversityofcelltypes.Heretheauthorsperformsingle-cellprofilingofneuralcresttoidentifykeyenhancersandtranscriptionfactorsforcellfatecompetency,thusrevealingprogressiveacquisitionoffatepotential. PeterFabian,Kuo-ChangTseng & J.GageCrump NatureCommunications13,13 Research 01December2021 | OpenAccess HistonevariantH2A.Zregulateszygoticgenomeactivation Duringembryogenesis,thegenomebecomestranscriptionallyactiveinaprocessknownaszygoticgenomeactivation(ZGA);howZGAisinitiatedisstillanopenquestion.HeretheauthorsshowhistonevariantH2A.ZdepositionprecedesRNApolymeraseIIbindingonchromatin,beforeZGA.H2A.ZlosscausestranscriptionaldownregulationofZGAgenesandleadstochangesinthe3Dgenomeorganization. DafneIbarra-Morales,MichaelRauer & NicolaIovino NatureCommunications12,7002 AllResearch&Reviews NewsandComment News&Views | 07March2022 Dippingatoeinthefountainofyouth Inculturedcellsandinmicewithacceleratedaging,briefburstsofYamanakareprogrammingfactorsreversesomemolecularandfunctionaldeficitsofagingwithoutinducingpluripotencyorteratomas.Browderetal.showthatpartialreprogrammingregimensrejuvenatesometissuesofphysiologicallyagedmicewithoutovertsafetyconcerns. AriannaMarkel & GeorgeQ.Daley NatureAging2,192-194 News&Views | 07February2022 Spermgranulesmediateepigeneticinheritance Epigeneticinheritanceisthetransferofnon-DNAinformationacrossgenerations.Anewstudyidentifiessperm-specificPEIgranulesasessentialforpaternalepigeneticinheritance.PEIgranulepartitioningtospermrequirespalmitoylationandmyosinVIactivity,suggestinglipidation-dependentgranuletransportonvesicles. LauraThomas & GeraldineSeydoux NatureCellBiology24,129-130 Correspondence 21September2021 | OpenAccess ThecomprehensiveDNAmethylationlandscapeofhematopoieticstemcelldevelopment XianlongLi,DiLiu & YuLan CellDiscovery7,86 ResearchHighlights 07September2020 | OpenAccess HowmammalianpiRNAsinstructdenovoDNAmethylationoftransposons ZhiqingLi,XiaoyinTang & En-ZhiShen SignalTransductionandTargetedTherapy5,190 News&Views | 30March2020 Settingthechromatinstageinoocytes Post-translationalhistonemodificationsareimportantregulatorsofnuclearreprogramming.AstudynowrevealsthathistonelysinedemethylaseKDM4A-mediatedH3K9me3demethylationinmammalianoocytesisessentialforzygoticgenomeactivationandpreimplantationdevelopment. JulieBrind’Amour & MatthewC.Lorincz NatureCellBiology22,355-357 Correspondence 29January2019 | OpenAccess DifferentialrolesofStellainthemodulationofDNAmethylationduringoocyteandzygoticdevelopment LongsenHan,ChaoRen & QiangWang CellDiscovery5,9 AllNews&Comment Search Searcharticlesbysubject,keywordorauthor Showresultsfrom Alljournals Search Advancedsearch Quicklinks Explorearticlesbysubject Findajob Guidetoauthors Editorialpolicies