Fenofibrate: Generic, Uses, Side Effects, Dosages ... - RxList

What Are Side Effects Associated with Using Fenofibrate? · Muscle pain · Muscle disease · Muscle inflammation · Diarrhea · Gas (flatulence) · Pancreatitis · Peptic ... Fenofibrate GenericName:Fenofibrate BrandName:Fenofibrate,Lipofen,Triglide,Tricor,Fenoglide DrugClass:FibricAcidAgents MedicalandPharmacyEditor: JohnP.Cunha,DO,FACOEP Reviewedon3/28/2022 consumer_fenofibrate_tricor Uses WhatIsFenofibrateandHowDoesItWork? Dosage WhatAreDosagesofFenofibrate? SideEffects WhatAreSideEffectsAssociatedwithUsingFenofibrate? DrugInteractions WhatOtherDrugsInteractwithFenofibrate? WarningsandPrecautions WhatAreWarningsandPrecautionsforFenofibrate? WhatIsFenofibrateandHowDoesItWork? Fenofibrateisusedalongwithaproperdiettohelplower"bad"cholesterolandfats(suchasLDL,triglycerides)andraise"good"cholesterol(HDL)intheblood.Itworksbyincreasingthenaturalsubstance(enzyme)thatbreaksdownfatsintheblood.Fenofibratebelongstoagroupofdrugsknownas"fibrates."Loweringtriglyceridesinpeoplewithveryhightriglyceridebloodlevelsmaydecreasetheriskofpancreasdisease(pancreatitis).However,fenofibratemightnotloweryourriskofaheartattackorstroke.Talktoyourdoctorabouttherisksandbenefitsoffenofibrate. Inadditiontoeatingaproperdiet(suchasalow-cholesterol/low-fatdiet),otherlifestylechangesthatmayhelpfenofibrateworkbetterinclude exercising, losingweightifoverweight,and stoppingsmoking. Consultyourdoctorformoredetails. Fenofibrateisavailableunderthefollowingdifferentbrandnames:Tricor,Lofibratablets,Fenoglide,Lipofen,andTriglide. WhatAreDosagesofFenofibrate? DosagesofFenofibrate: DosageFormsandStrengths TriCortablet 48mg 145mg Lofibratablet 54mg 160mg Fenoglidetablet 40mg 120mg Triglidetablet 160mg Lipofencapsule 50mg 150mg DosageConsiderations–ShouldbeGivenasFollows: Pediatric:Safetyandefficacynotestablished TriCor Hypercholesterolemia,mixeddyslipidemia:Initially,145mgorallyonce/day Hypertriglyceridemia:Initially,48-145mgorallyonce/day Titrateevery4-8weeksuptonomorethan145mgorallyonce/day Geriatric,initial:48mg/day;evaluatebeforeincreasedose Triglide Hypercholesterolemia,MixedDyslipidemia:initial160mgorallyonce/day Hypertriglyceridemia:50-160mgorallyonce/dayinitially Geriatric,initial:50mg/day Lipofen Hypercholesterolemia,MixedDyslipidemia:initial150mgorallyonce/day Hypertriglyceridemia:initial50-150mgorallyonce/day Geriatric,initial:Nomorethan50mg/day Lofibratablets Hypercholesterolemia,MixedDyslipidemia:160mgorallyonce/day Hypertriglyceridemia:54-160mgorallyonce/day Geriatric,initial:54mg/day Fenoglide Hypercholesterolemia,MixedDyslipidemia:120mgorallyonce/day Hypertriglyceridemia:40-120mgorallyonce/day Geriatric,initial:40mg/day DosageConsiderations Overdosemanagement SymptomsincludeGIdistress Treatmentissupportive DosingModifications Renalimpairment(CrCllessthan50mL/min): TriCor:Initial,48mg/dayinitially;evaluatebeforeincreasedose Triglide:Initial,50mg/day Lipofen:Initial,nomorethan50mg/day Lofibratablets:Initial,54mg/day Fenoglide:Initial,40mg/day Administration TriCor,Triglide,andLofibratabletscanbetakenwithoutregardtomeals Lipofen:Takewithmeals SLIDESHOW HowtoLowerYourCholesterol&SaveYourHeart SeeSlideshow WhatAreSideEffectsAssociatedwithUsingFenofibrate? SideeffectsassociatedwiththeuseofFenofibrate,includethefollowing: Increasedliverfunctiontests(LFT's)(dose-related) Respiratorydisorder Abdominalpain Backpain CPKincreased Headache Constipation Nausea Runnyorstuffynose Postmarketingsideeffectsoffenofibratereportedinclude: Musclepain Muscledisease Muscleinflammation Diarrhea Gas(flatulence) Pancreatitis Pepticulcer Cholelithiasis Centralnervoussystem(CNS)depression Abnormalheartrhythms Peripheralvasculardisease Bloodclotinthelung(pulmonaryembolus) Kidneydamage Rash Anemia Lowwhitebloodcellcount(leukopenia) Thisdocumentdoesnotcontainallpossiblesideeffectsandothersmayoccur.Checkwithyourphysicianforadditionalinformationaboutsideeffects.WhatOtherDrugsInteractwithFenofibrate? Ifyourdoctorhasdirectedyoutousethismedication,yourdoctororpharmacistmayalreadybeawareofanypossibledruginteractionsandmaybemonitoringyouforthem.Donotstart,stop,orchangethedosageofanymedicinebeforecheckingwithyourdoctor,healthcareprovider,orpharmacistfirst. Severeinteractionsoffenofibrateinclude: None SeriousInteractionsoffenofibrateinclude: atorvastatin colchicine fluvastatin idelalisib ivacaftor lovastatin pitavastatin pravastatin rosuvastatin simvastatin warfarin Fenofibratehasmoderateinteractionswithatleast26differentdrugs. MildInteractionsoffenofibrateinclude: colestipol cyclosporine ezetimibe octacosanol Thisinformationdoesnotcontainallpossibleinteractionsoradverseeffects.Therefore,beforeusingthisproduct,tellyourdoctororpharmacistofalltheproductsyouuse.Keepalistofallyourmedicationswithyou,andsharethisinformationwithyourdoctorandpharmacist.Checkwithyourhealthcareprofessionalordoctorforadditionalmedicaladvice,orifyouhavehealthquestions,concerns,orformoreinformationaboutthismedicine. WhatAreWarningsandPrecautionsforFenofibrate? Warnings Thismedicationcontainsfenofibrate.DonottakeTricor,Lofibratablets,Fenoglide,Lipofen,andTriglideifyouareallergictofenofibrateoranyingredientscontainedinthisdrug Keepoutofreachofchildren.Incaseofoverdose,getmedicalhelporcontactaPoisonControlCenterimmediately Contraindications Knownhypersensitivity Severerenalimpairment,includingthosewithend-stagerenaldiseaseandthosereceivingdialysis Activeliverdisease Gallbladderdisease Nursingmothers EffectsofDrugAbuse Noinformationprovided Short-TermEffects See"WhatAreSideEffectsAssociatedwithUsingFenofibrate?" Long-TermEffects See"WhatAreSideEffectsAssociatedwithUsingFenofibrate?” Cautions Cholelithiasisreportedwithuse;discontinueifgallstonesdetectedupongallbladderstudies Raremyopathy,myositis,orrhabdomyolysisreportedwithuse;monitor Increaseinhepatictransaminasesreported;discontinueifenzymelevelspersist3timesabovetheupperlimitofnormal Reversiblyincreasesserumcreatininelevels;considermonitoringrenalfunctioninpatientsatriskforrenalimpairment Thrombocytopeniaandagranulocytosisreported;monitorbloodcountsperiodicallyduringthefirstyearoftherapy Associatedwithpulmonaryembolismanddeepvenousthrombosis;usecautioninpatientswithriskfactorsforvenousthromboembolism(VTE) Concomitantusewithoralanticoagulants(monitorandadjustwarfarindoseasneeded) MayfurtherincreasetheriskforrhabdomyolysiswhenaddedtooptimalHMG-CoAreductaseinhibitorregimentofurtherdecreasetriglyceridesandincreaseHDLs ParadoxicaldecreasesinHDLcholesterol(HDL-C)levelreported Ruleoutsecondarycausesofhyperlipidemiabeforeinitiatingtherapy Withdrawtherapyifnoadequateresponseseenafter2-3months Usewithcautionintheelderly;doseadjustmentsmaybenecessary Fenofibrateincreasescholesterolexcretionintothebile,leadingtoariskofcholelithiasis;performgallbladderstudiesifcholelithiasissuspected Fabricacidderivativesasmonotherapyorincombinationwithsimvastatinhavenotbeenshowntosignificantlyreducecardiovascularmortalityinmajorclinicalstudies PregnancyandLactation Usefenofibratewithcautionduringpregnancyifthebenefitsoutweightherisks.Animalstudiesshowriskandhumanstudiesarenotavailable,orneitheranimalnorhumanstudiesweredone Itisunknowniffenofibrateisexcretedinbreastmilk;itisnotrecommendedforusewhilebreastfeeding QUESTION Whatischolesterol? SeeAnswer From CholesterolResources LivingWithHighCholesterol FeaturedCenters WhatAretheBestPsATreatmentsforYou?UnderstandingBiologics 10ThingsPeopleWithDepressionWishYouKnew HealthSolutionsFromOurSponsors Shot-FreeMSTreatment YourChildandCOVID-19 References SOURCE: Medscape.Fenofibrate. https://reference.medscape.com/drug/tricor-lofibra-tablets-fenofibrate-342451 PillIdentifierToolQuick,Easy,PillIdentification DrugInteractionToolCheckPotentialDrugInteractions PharmacyLocatorToolIncluding24Hour,Pharmacies HealthSolutionsFromOurSponsors PenisCurvedWhenErect CouldIhaveCAD? TreatBentFingers TreatHR+,HER2-MBC TiredofDandruff? LifewithCancer