Fenofibrate Side Effects: Common, Severe, Long Term

Side effects requiring immediate medical attention · Chills · fever · hives, itching, skin rash · muscle aches and pains · nausea · stomach pain ... Skiptomaincontent Close DrugsAtoZ Fenofibrate SideEffects Print Save FenofibrateSideEffects MedicallyreviewedbyDrugs.com.LastupdatedonMar20,2022. Consumer Professional SummaryCommonlyreportedsideeffectsoffenofibrateinclude:increasedserumaspartateaminotransferaseandincreasedserumalanineaminotransferase.Othersideeffectsinclude:abnormalhepaticfunctiontests,increasedcreatinephosphokinaseinbloodspecimen,andincreasedserumtransaminases.Seebelowforacomprehensivelistofadverseeffects.FortheConsumerAppliestofenofibrate:oralcapsule,oraltablet SideeffectsrequiringimmediatemedicalattentionAlongwithitsneededeffects,fenofibratemaycausesomeunwantedeffects.Althoughnotallofthesesideeffectsmayoccur,iftheydooccurtheymayneedmedicalattention. Checkwithyourdoctorimmediatelyifanyofthefollowingsideeffectsoccurwhiletakingfenofibrate: Lesscommon Chills fever hives,itching,skinrash muscleachesandpains nausea stomachpain vomiting Rare Darkurine musclecramps,spasms,stiffness,swelling,orweakness troublebreathing unusualbleedingorbruising unusualtirednessorweakness yelloweyesorskin Incidencenotknown Agitation bloating bloodyurine constipation cough decreasedfrequencyoramountofurine difficultyinmoving fastheartbeat increasedbloodpressure increasedthirst indigestion jointpainorswelling light-coloredstools lossofappetite lowerbackorsidepain painsinthestomach,side,orabdomen,possiblyradiatingtotheback paleskin swellingoftheface,fingers,orlowerlegs upperrightstomachpain weightgain SideeffectsnotrequiringimmediatemedicalattentionSomesideeffectsoffenofibratemayoccurthatusuallydonotneedmedicalattention.Thesesideeffectsmaygoawayduringtreatmentasyourbodyadjuststothemedicine.Also,yourhealthcareprofessionalmaybeabletotellyouaboutwaystopreventorreducesomeofthesesideeffects. Checkwithyourhealthcareprofessionalifanyofthefollowingsideeffectscontinueorarebothersomeorifyouhaveanyquestionsaboutthem: Morecommon Runnyorstuffynose sneezing Lesscommon Backpain diarrhea eyeirritation gas increasedsensitivityoftheskintosunlight Incidencenotknown Lackorlossofstrength ForHealthcareProfessionalsAppliestofenofibrate:oralcapsule,oraltabletGeneralThemostfrequentlyreportedsideeffectshaveincludedabnormallivertests,increasedtransaminases(ALTandAST),increasedcreatinephosphokinase(CPK),andrhinitis.[Ref]HepaticCommon(1%to10%):Liverfunctiontestsabnormal,ASTincreased,ALTincreased Uncommon(0.1%to1%):Cholelithiasis Rare(lessthan0.1%):Hepatitis Postmarketingreports:Cirrhosis,liverfattydeposit,cholecystitis,jaundice,cholangitis,biliarycolic,elevatedtotalbilirubin,seriousdrug-inducedliverinjuryincludinglivertransplantationanddeath[Ref]Duringclinicaltrials,transaminaseincreasestogreaterthan3timestheupperlimitofnormal(3xULN)occurredin5.3%ofpatientstakingfenofibratecomparedwith1.1%ofthoseonplacebo;theincidenceofincreasedtransaminasesappearedtobedose-related.[Ref]RespiratoryVerycommon(10%ormore):Rhinitis(upto23.2%),bronchitis(16.4%) Common(1%to10%):Respiratorydisorder,pharyngitis,sinusitis Uncommon(0.1%to1%):Pulmonaryembolism Veryrare(lessthan0.01%):Interstitialpneumopathy Frequencynotreported:Coughincreased,dyspnea,asthma,pneumonia,laryngitis Postmarketingreports:Interstitiallungdisease[Ref]MusculoskeletalVerycommon(10%ormore):Arthralgia(upto25.1%),backpain(upto15%) Common(1%to10%):Backpain,myalgia Uncommon(0.1%to1%):Diffusemyalgia,myositis,musclecramp,muscleweakness Veryrare(lessthan0.01%):Rhabdomyolysis Frequencynotreported:Arthritis,tenosynovitis,jointdisorder,arthrosis,legcramp,bursitis,myasthenia Postmarketingreports:Musclespasm[Ref]GastrointestinalVerycommon(10%ormore):Abdominalpain(upto15.9%) Common(1%to10%):Nausea,constipation,diarrhea,vomiting,flatulence Uncommon(0.1%to1%):Pancreatitis Frequencynotreported:Dyspepsia,gastroenteritis,rectaldisorder,esophagitis,gastritis,colitis,toothdisorder,gastrointestinaldisorder,duodenalulcer,pepticulcer,rectalhemorrhage,eructation,gammaglutamyltranspeptidase,drymouth[Ref]NervoussystemCommon(1%to10%):Headache,dizziness Rare(lessthan0.1%):Peripheralneuropathy Frequencynotreported:Migraine,paresthesia,hypertonia,neuralgia,somnolence[Ref]DermatologicPhotosensitivityreactionshavebeenreporteddaystomonthsafterinitiation;insomecases,apriorphotosensitivityreactiontoketoprofenhadbeenreported.[Ref]Common(1%to10%):Rash,pruritus,urticaria Uncommon(0.1%to1%):Photosensitivityreaction Rare(0.01%to0.1%):Alopecia Veryrare(lessthan0.01%):Cutaneousphotosensitivitywitherythema,vesiculation,nodulation Frequencynotreported:Erythemamultiforme,Stevens-Johnsonsyndrome,toxicepidermalnecrolysis,eczema,acne,sweating,fungaldermatitis,skindisorder,contactdermatitis,maculopapularrash,naildisorder,skinulcer Postmarketingreports:Severecutaneousadversedrugreactions(SCAR),includingStevens-JohnsonSyndrome,ToxicEpidermalNecrolysis,andDrugReactionwithEosinophiliaandSystemicSymptoms(DRESS),ecchymosis[Ref]CardiovascularUncommon(0.1%to1%):Deepveinthrombosis Frequencynotreported:Anginapectoris,hypertension,vasodilatation,coronaryarterydisorder,electrocardiogramabnormal,extrasystole,myocardialinfarct,peripheralvasculardisorder,varicosevein,cardiovasculardisorder,hypotension,palpitation,arrhythmia,phlebitis,tachycardia,atrialfibrillation[Ref]OcularCommon(1%to10%):Conjunctivitis Frequencynotreported:Eyedisorder,amblyopia,abnormalvision,cataractspecified,refractiondisorder[Ref]OtherVerycommon(10%ormore):Accidentalinjury(upto18.4%),flusyndrome(upto17.9%),chestpain(upto10.1%) Common(1%to10%):Creatinephosphokinaseincreased,malaise,vertigo,fatigue Uncommon(0.1%to1%):Serumcreatinineincreased,ureaincreased Rare(lessthan0.1%):Sexualasthenia Frequencynotreported:Pain,infection,cyst,hernia,fever,peripheraledema,earpain,otitismedia,herpeszoster,herpessimplex,weightgain,weightloss,edema Postmarketingreports:Asthenia[Ref]GenitourinaryUncommon(0.1%to1%):Sexualdysfunction Frequencynotreported:Urinaryfrequency,prostaticdisorder,dysuria,gynecomastia,vaginalmoniliasis,cystitis[Ref]HematologicRare(lessthan0.1%):Hemoglobindecreased,leukopenia Frequencynotreported:Eosinophilia,lymphadenopathy,thrombocytopenia,anemia Postmarketingreports:Hematocritdecreased[Ref]MetabolicFrequencynotreported:Appetiteincreased,anorexia,diabetesmellitus,hypoglycemia,gout,hyperuricemia Postmarketingreports:High-densitylipoproteincholesterollevelsseverelydepressed[Ref]RenalFrequencynotreported:Kidneyfunctionabnormal,urolithiasis Postmarketingreports:Renalfailure,acuterenalfailure[Ref]PsychiatricCommon(1%to10%):Insomnia Frequencynotreported:Depression,libidodecreased,anxiety,nervousness[Ref]EndocrineFrequencynotreported:Diabetesmellitus[Ref]HypersensitivityRare(lessthan0.1%):Hypersensitivityreaction Frequencynotreported:Allergicreaction[Ref] Moreaboutfenofibrate Druginteractions Dosageinformation Duringpregnancyor Breastfeeding Reviews(62) Patienttips Drugimages Comparealternatives Pricing&coupons Enespañol Drugclass:fibricacidderivatives Patientresources DrugInformation Fenofibrate(AdvancedReading) FenofibrateandDerivativesCapsules FenofibrateandDerivativesTablets OtherbrandsTriCor,Lofibra,Triglide,Fenoglide,...+2more Professionalresources PrescribingInformation Relatedtreatmentguides Hypertriglyceridemia Hyperlipoproteinemia HyperlipoproteinemiaTypeIIa,ElevatedLDL HyperlipoproteinemiaTypeIIb,ElevatedLDLVLDL HyperlipoproteinemiaTypeIV,ElevatedVLDL HyperlipoproteinemiaTypeV,ElevatedChylomicronsVLDL References1."ProductInformation.Tricor(fenofibrate)."AbbottPharmaceutical(2001):2.CernerMultum,Inc."UKSummaryofProductCharacteristics."O03.CernerMultum,Inc."AustralianProductInformation."O04."ProductInformation.Antara(fenofibrate)."LupinPharmaceuticalsInc(2016):5."ProductInformation.Fenoglide(fenofibrate)."SantarusInc(2016):6."ProductInformation.Lipofen(fenofibrate)."KowaPharmaceuticalsAmerica(formerlyProEthic)(2016):7."ProductInformation.Triglide(fenofibrate)."ScielePharmaInc(2016):8."ProductInformation.Fenofibrate(fenofibrate)."MylanPharmaceuticalsInc(2016):FurtherinformationAlwaysconsultyourhealthcareprovidertoensuretheinformationdisplayedonthispageappliestoyourpersonalcircumstances. Somesideeffectsmaynotbereported.YoumayreportthemtotheFDA. MedicalDisclaimer DrugStatus Availability Prescriptiononly Rx Pregnancy&Lactation Riskdataavailable CSASchedule* Notacontrolleddrug N/A Loading... ApprovalHistory DrughistoryatFDA Loading... UserReviews&Ratings 5.8/10 62Reviews RelatedDrugs atorvastatin,simvastatin,rosuvastatin,Lipitor,fenofibrate,Crestor,gemfibrozil,Vascepa,niacin,FishOil Images Fenofibratesystemic67mg(G0511G0511) Viewallimages