Fenofibrate Dosage Guide + Max Dose, Adjustments

Usual Adult Dose for Hyperlipidemia. Multiple products available: 1 capsule or tablet orally once a day (range: 90 to 200 mg per dose unit) Skiptomaincontent Close DrugsAtoZ Fenofibrate Dosage Print Save FenofibrateDosage MedicallyreviewedbyDrugs.com.LastupdatedonMar8,2022. Appliestothefollowingstrengths:48mg;145mg;54mg;160mg;67mg;micronized200mg;134mg;40mg;120mg;43mg;130mg;30mg;90mg;50mg;150mg UsualAdultDosefor: Hyperlipidemia HyperlipoproteinemiaTypeIIa(ElevatedLDL) HyperlipoproteinemiaTypeIIb(ElevatedLDL+VLDL) Dyslipidemia HyperlipoproteinemiaTypeIV(ElevatedVLDL) HyperlipoproteinemiaTypeV(ElevatedChylomicrons+VLDL) Hypertriglyceridemia Additionaldosageinformation: RenalDoseAdjustments LiverDoseAdjustments DoseAdjustments Precautions Dialysis OtherComments UsualAdultDoseforHyperlipidemia Multipleproductsavailable: 1capsuleortabletorallyonceaday(range:90to200mgperdoseunit) -Maximumdose:1tabletorcapsuleorallyonceaday Someexamplesofbrandedtabletsandcapsules;multiplegenericsavailable: -Antara(micronizedcapsules):90and130mg -Lipofen(capsules):150mg -Fenoglide(tablet):120mg -Tricor(tablet):145mg -Triglide(tablet):160mg -Fenofibrate(micronized)capsules:200mg Comments: -Therapyshouldbewithdrawnifinadequateresponseafter2monthsoftreatment. -Thisdrugisintendedtoreduceelevatedlow-densitylipoproteincholesterol(LDL-C),totalcholesterol(Total-C),triglycerides(TG),andapolipoproteinB(ApoB),andtoincreasehigh-densitylipoprotein(HDL-C)inpatientswithprimaryhypercholesterolemiaormixeddyslipidemia. Uses:Asanadjuncttherapytodietforthetreatmentofprimaryhypercholesterolemiaandmixeddyslipidemia. UsualAdultDoseforHyperlipoproteinemiaTypeIIa(ElevatedLDL) Multipleproductsavailable: 1capsuleortabletorallyonceaday(range:90to200mgperdoseunit) -Maximumdose:1tabletorcapsuleorallyonceaday Someexamplesofbrandedtabletsandcapsules;multiplegenericsavailable: -Antara(micronizedcapsules):90and130mg -Lipofen(capsules):150mg -Fenoglide(tablet):120mg -Tricor(tablet):145mg -Triglide(tablet):160mg -Fenofibrate(micronized)capsules:200mg Comments: -Therapyshouldbewithdrawnifinadequateresponseafter2monthsoftreatment. -Thisdrugisintendedtoreduceelevatedlow-densitylipoproteincholesterol(LDL-C),totalcholesterol(Total-C),triglycerides(TG),andapolipoproteinB(ApoB),andtoincreasehigh-densitylipoprotein(HDL-C)inpatientswithprimaryhypercholesterolemiaormixeddyslipidemia. Uses:Asanadjuncttherapytodietforthetreatmentofprimaryhypercholesterolemiaandmixeddyslipidemia. UsualAdultDoseforHyperlipoproteinemiaTypeIIb(ElevatedLDL+VLDL) Multipleproductsavailable: 1capsuleortabletorallyonceaday(range:90to200mgperdoseunit) -Maximumdose:1tabletorcapsuleorallyonceaday Someexamplesofbrandedtabletsandcapsules;multiplegenericsavailable: -Antara(micronizedcapsules):90and130mg -Lipofen(capsules):150mg -Fenoglide(tablet):120mg -Tricor(tablet):145mg -Triglide(tablet):160mg -Fenofibrate(micronized)capsules:200mg Comments: -Therapyshouldbewithdrawnifinadequateresponseafter2monthsoftreatment. -Thisdrugisintendedtoreduceelevatedlow-densitylipoproteincholesterol(LDL-C),totalcholesterol(Total-C),triglycerides(TG),andapolipoproteinB(ApoB),andtoincreasehigh-densitylipoprotein(HDL-C)inpatientswithprimaryhypercholesterolemiaormixeddyslipidemia. Uses:Asanadjuncttherapytodietforthetreatmentofprimaryhypercholesterolemiaandmixeddyslipidemia. UsualAdultDoseforDyslipidemia Multipleproductsavailable: 1capsuleortabletorallyonceaday(range:90to200mgperdoseunit) -Maximumdose:1tabletorcapsuleorallyonceaday Someexamplesofbrandedtabletsandcapsules;multiplegenericsavailable: -Antara(micronizedcapsules):90and130mg -Lipofen(capsules):150mg -Fenoglide(tablet):120mg -Tricor(tablet):145mg -Triglide(tablet):160mg -Fenofibrate(micronized)capsules:200mg Comments: -Therapyshouldbewithdrawnifinadequateresponseafter2monthsoftreatment. -Thisdrugisintendedtoreduceelevatedlow-densitylipoproteincholesterol(LDL-C),totalcholesterol(Total-C),triglycerides(TG),andapolipoproteinB(ApoB),andtoincreasehigh-densitylipoprotein(HDL-C)inpatientswithprimaryhypercholesterolemiaormixeddyslipidemia. Uses:Asanadjuncttherapytodietforthetreatmentofprimaryhypercholesterolemiaandmixeddyslipidemia. UsualAdultDoseforHyperlipoproteinemiaTypeIV(ElevatedVLDL) Dosingisproductspecific;availableasmicronizedcapsules,capsules,andtablets: MICRONIZEDCAPSULES: -Antara:Initialdose:30to90mgorallyonceaday;maximumdose:90mg/day -Antara:Initialdose:43to130mgorallyonceaday;maximumdose:130mg/day -Fenofibrate:Initialdose:67to200mgorallyonceaday;maximumdose200mg/day CAPSULES: -Lipofen:Initialdose:50to150mgorallyonceaday;maximumdose:150mg/day TABLETS: -Fenoglide:Initialdose:40to120mgorallyonceaday;maximumdose:120mg/day -Tricor:Initialdose:48to145mgorallyonceaday:maximumdose145mg/day -Fenofibrate:Initialdose:54to160mgorallyonceaday;maximumdose:160mg/day -Triglide:160mgorallyonceaday;maximumdose:160mg/day TITRATION:Individualizedoseaccordingtoresponseandadjustasnecessaryfollowingrepeatlipiddeterminationsat4to8weekintervals;iflipidlevelsfallsignificantly,dosereductionshouldbeconsidered. Comments: -Therapyshouldbewithdrawnifinadequateresponseafter2monthsoftreatmentwiththemaximumrecommendeddose. Use:Asanadjuncttodietforthetreatmentofseverehypertriglyceridemia. UsualAdultDoseforHyperlipoproteinemiaTypeV(ElevatedChylomicrons+VLDL) Dosingisproductspecific;availableasmicronizedcapsules,capsules,andtablets: MICRONIZEDCAPSULES: -Antara:Initialdose:30to90mgorallyonceaday;maximumdose:90mg/day -Antara:Initialdose:43to130mgorallyonceaday;maximumdose:130mg/day -Fenofibrate:Initialdose:67to200mgorallyonceaday;maximumdose200mg/day CAPSULES: -Lipofen:Initialdose:50to150mgorallyonceaday;maximumdose:150mg/day TABLETS: -Fenoglide:Initialdose:40to120mgorallyonceaday;maximumdose:120mg/day -Tricor:Initialdose:48to145mgorallyonceaday:maximumdose145mg/day -Fenofibrate:Initialdose:54to160mgorallyonceaday;maximumdose:160mg/day -Triglide:160mgorallyonceaday;maximumdose:160mg/day TITRATION:Individualizedoseaccordingtoresponseandadjustasnecessaryfollowingrepeatlipiddeterminationsat4to8weekintervals;iflipidlevelsfallsignificantly,dosereductionshouldbeconsidered. Comments: -Therapyshouldbewithdrawnifinadequateresponseafter2monthsoftreatmentwiththemaximumrecommendeddose. Use:Asanadjuncttodietforthetreatmentofseverehypertriglyceridemia. UsualAdultDoseforHypertriglyceridemia Dosingisproductspecific;availableasmicronizedcapsules,capsules,andtablets: MICRONIZEDCAPSULES: -Antara:Initialdose:30to90mgorallyonceaday;maximumdose:90mg/day -Antara:Initialdose:43to130mgorallyonceaday;maximumdose:130mg/day -Fenofibrate:Initialdose:67to200mgorallyonceaday;maximumdose200mg/day CAPSULES: -Lipofen:Initialdose:50to150mgorallyonceaday;maximumdose:150mg/day TABLETS: -Fenoglide:Initialdose:40to120mgorallyonceaday;maximumdose:120mg/day -Tricor:Initialdose:48to145mgorallyonceaday:maximumdose145mg/day -Fenofibrate:Initialdose:54to160mgorallyonceaday;maximumdose:160mg/day -Triglide:160mgorallyonceaday;maximumdose:160mg/day TITRATION:Individualizedoseaccordingtoresponseandadjustasnecessaryfollowingrepeatlipiddeterminationsat4to8weekintervals;iflipidlevelsfallsignificantly,dosereductionshouldbeconsidered. Comments: -Therapyshouldbewithdrawnifinadequateresponseafter2monthsoftreatmentwiththemaximumrecommendeddose. Use:Asanadjuncttodietforthetreatmentofseverehypertriglyceridemia. RenalDoseAdjustments Mildtomoderaterenaldysfunction:Initiateatlowerdosesandincreaseonlyafterevaluatingtheeffectsoftherapyonrenalfunctionandlipidlevels: -Antara(micronizedcapsules):Initialdose:30mgorallyonceaday;maximumdose:90mgorallyonceaday -Antara(micronizedcapsules):Initialdose:43mgorallyonceaday;maximumdose:130mgorallyonceaday -Fenofibrate(micronizedcapsules):Initialdose:67mgorallyonceaday;maximumdose:200mgorallyonceaday -Fenofibrate(tablets):Initialdose:54mgorallyonceaday;maximumdose:160mgorallyonceaday -Lipofen(capsules):Initialdose:50mgorallyonceaday;maximumdose:150mgorallyonceaday -Fenoglide(tablets):Initialdose:40mgorallyonceaday;maximumdose:120mgorallyonceaday -Tricor(tablets):Initialdose:48mgorallyonceaday;maximumdose:145mgorallyonceaday Severerenalimpairment:Contraindicated LiverDoseAdjustments Activeliverdisease:Contraindicated -Monitorliverfunctiontests,includingserumALT,AST,andtotalbilirubin;discontinueifsignsorsymptomsofliverinjurydeveloporifelevatedenzymelevelspersist(ALTorASTgreaterthan3timestheupperlimitofnormal,orifaccompaniedbyelevationofbilirubin DoseAdjustments Elderly:Duetothehigherincidenceofrenalimpairmentinthispatientpopulation,doseselectionshouldbebasedonrenalfunction;monitorrenalfunctionduringtherapy Precautions CONTRAINDICATIONS: -Hypersensitivitytofenofibrate,fenofibricacid,oranyproductexcipients -Activeliverdiseaseincludingprimarybiliarycirrhosisandunexplainedpersistentliverfunctionabnormalities -Severerenalimpairment,includingdialysis -Preexistinggallbladderdisease -Lactation Safetyandefficacyhavenotbeenestablishedinpatientsyoungerthan18years. ConsultWARNINGSsectionforadditionalprecautions. Dialysis Contraindicated OtherComments Administrationadvice: -Maybetakenwithfoodtoincreaseabsorption -Swallowcapsulesandtabletswhole;donotbreak,open,crush,dissolve,orchew Concomitantusewithbileacidbindingresin: -Takeatleast1hourbeforeor4to6hoursafterbileacidbindingresin Storagerequirements: -Protectfromlightandmoisture -Triglide(R):Dispenseinoriginalbottle General: -Priortoinitiatingtherapy,diseasescontributingtohyperlipidemiashouldbeassessedandadequatelytreated;medicationsassociatedwithelevatedtriglyceridesshouldbeevaluated. -Inpatientswithtype2diabetesshowingfastingchylomicronemia,improvingglycemiccontrolmayreducefastingtriglyceridesandeliminateneedfordrugtreatment. -Initialtreatmentfordyslipidemiashouldbedietaryspecifictargetedatthetypeoflipoproteinabnormality. -Thisdrughasnotbeenshowntoreducecoronaryheartdiseasemorbidityandmortalityinpatientswithtype2diabetesmellitus. -Markedlyelevatedlevelsofserumtriglycerides(e.g.greaterthan2000mg/dL)mayincreasetheriskofdevelopingpancreatitis;theeffectofthisdrugonreducingthisriskhasnotbeenadequatelystudied. Monitoring: -Hematologic:MonitorRBCandWBCcountsperiodicallyduringthefirst12monthsoftherapy -Hepatic:Measureliverfunctionatbaselineandperiodicallyduringtherapy -Metabolic:Periodicallymeasurelipidlevelsandadjustdoseaccordingly -Renal:Monitorrenalfunctioninpatientswithrenalimpairmentorthoseatriskforrenalinsufficiency(e.g.,elderly) -MorefrequentPT/INRmonitoringuntilPT/INRstabilizes Patientadvice: -Patientsshouldbeinstructedtofollowalipid-modifyingdietduringtherapy. -Patientsshouldbeinstructedtoimmediatelyinformtheirphysicianofsymptomsofliverinjury(e.g.,jaundice,abnormalpain,nausea,malaise,darkurine,abnormalstool,pruritus);anymusclepain,tenderness,orweakness;onsetofabdominalpain;oranyothernewsymptoms. -Patientsshouldbeinstructedtonotifytheirhealthcareproviderofallmedications,supplements,andherbalpreparationstheyaretaking. -Patientsshouldbeinstructedtotalktotheirhealthcareprovideriftheyarepregnant,planningtobecomepregnant,orbreastfeeding;womenshouldnotbreastfeedduringtreatmentandfor5daysafterthefinaldose. Moreaboutfenofibrate Sideeffects Druginteractions Duringpregnancyor Breastfeeding Reviews(62) Patienttips Drugimages Comparealternatives Pricing&coupons Enespañol Drugclass:fibricacidderivatives Patientresources DrugInformation Fenofibrate(AdvancedReading) FenofibrateandDerivativesCapsules FenofibrateandDerivativesTablets OtherbrandsTriCor,Lofibra,Triglide,Fenoglide,...+2more Professionalresources PrescribingInformation Relatedtreatmentguides Hypertriglyceridemia Hyperlipoproteinemia HyperlipoproteinemiaTypeIIa,ElevatedLDL HyperlipoproteinemiaTypeIIb,ElevatedLDLVLDL HyperlipoproteinemiaTypeIV,ElevatedVLDL HyperlipoproteinemiaTypeV,ElevatedChylomicronsVLDL FurtherinformationAlwaysconsultyourhealthcareprovidertoensuretheinformationdisplayedonthispageappliestoyourpersonalcircumstances. 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