Systems biology - Latest research and news | Nature

Systems biology is the study of biological systems whose behaviour cannot be reduced to the linear sum of their parts' functions. Systems biology does not ... Skiptomaincontent Thankyouforvisitingnature.com.YouareusingabrowserversionwithlimitedsupportforCSS.Toobtain thebestexperience,werecommendyouuseamoreuptodatebrowser(orturnoffcompatibilitymodein InternetExplorer).Inthemeantime,toensurecontinuedsupport,wearedisplayingthesitewithoutstyles andJavaScript. Advertisement nature subjects systemsbiology Atom RSSFeed Systemsbiology Definition Systemsbiologyisthestudyofbiologicalsystemswhosebehaviourcannotbereducedtothelinearsumoftheirparts’functions.Systemsbiologydoesnotnecessarilyinvolvelargenumbersofcomponentsorvastdatasets,asingenomicsorconnectomics,butoftenrequiresquantitativemodellingmethodsborrowedfromphysics. Featured News&Views | 31March2022 Livingbuildingblocks KwokSoonWun,InYoungHwang & MatthewWookChang NatureMaterials21,382-383 News&Views | 28March2022 Antibodiesasprogrammable,bipedalwalkers NatureComputationalScience,1-2 News&Views | 21March2022 Giveandtakeintheexometabolome KevinR.Stindt & MeganN.McClean NatureMicrobiology7,484-485 RelatedSubjects Bayesianinference Biobricks Biochemicalnetworks Bioenergetics Cellularnoise Complexity Computermodelling Computerscience Controltheory Criticality Differentialequations DNAcomputingandcryptography Dynamicnetworks Dynamicalsystems Emergence Evolvability Geneticcircuitengineering Geneticinteraction Genomicengineering Informationtheory Logicgates Metabolicengineering Modularity Molecularengineering Molecularfluctuations Multicellularsystems Multistability Nonlineardynamics Numericalsimulations Oscillators Populationdynamics Programminglanguage Proteinengineering Regulatorynetworks Reverseengineering Robustness Signalprocessing Single-cellimaging Software Standardization Stochasticmodelling Stochasticnetworks Syntheticbiology Systemsanalysis Timeseries Showmore LatestResearchandReviews Research | 12April2022 CellComminferscellularcrosstalkthatdriveshaematopoieticstemandprogenitorcelldevelopment LummertzdaRochaetal.presentCellComm,analgorithmthatanalysescell–cellcommunicationtopredictsignallingandregulatorynetworks,andidentifyregulatorsofhaematopoieticdevelopmentintheaorta–gonad–mesonephrosregion. EdroaldoLummertzdaRocha,CarolineKubaczka & GeorgeQ.Daley NatureCellBiology,1-11 Research 12April2022 | OpenAccess Usinghigh-resolutioncontactnetworkstoevaluateSARS-CoV-2transmissionandcontrolinlarge-scalemulti-dayevents Here,theauthorssimulateCOVID-19outbreaksonanempiricalcontactnetworkderivedfromdigitalcontactdatacollectedoncruiseships.Theymodelimpactsofdifferentcontrolmeasuresandfindthatcombinationsofmeasures,particularlyvaccinationandrapidantigentesting,areimportantformitigatingoutbreaks. RachaelPung,JoshA.Firth & AdamJ.Kucharski NatureCommunications13,1956 Research 11April2022 | OpenAccess Single-cellcharacterizationofleukemicandnon-leukemicimmunerepertoiresinCD8+T-celllargegranularlymphocyticleukemia Tcelllargegranularlymphocyticleukemia(T-LGLL)isalymphoproliferativedisorderinvolvingclonallyexpandedTcellclonesandisnotfullyunderstood.HeretheauthorsshowthattherestoftheimmunerepertoireisinterconnectedwiththeT-LGLLclonotype(s)andismoremature,cytotoxicandclonallyrestrictedthaninothercancersandautoimmunedisorders. JaniHuuhtanen,DipabarnaBhattacharya & SatuMustjoki NatureCommunications13,1981 Research 08April2022 | OpenAccess Evokedresponsestorhythmicvisualstimulationvaryacrosssourcesofintrinsicalphaactivityinhumans R.Nuttall,C.Jäger & J.Dowsett ScientificReports12,5986 Research | 07April2022 Deeplearning-inferredmultipleximmunofluorescenceforimmunohistochemicalimagequantification Multipleximmunofluorescenceimagingcanprovideawealthofdatacomparedtoimmunohistochemicalstaining,whichischeaperandmorewidelyavailable.Ghahremanietal.presentDeepLIIF,aGAN-basedcellsegmentationandclassificationapproach,whichistrainedonco-registeredimagesofthesetwomodalitiestoprovidetheinsightsfromthemoredata-richmuliplexdatafromsimplerIHCimages. ParmidaGhahremani,YanyunLi & SaadNadeem NatureMachineIntelligence,1-12 Research 07April2022 | OpenAccess PromiscuitymappingoftheS100proteinfamilyusingahigh-throughputholdupassay MártonA.Simon,ÉvaBartus & LászlóNyitray ScientificReports12,5904 AllResearch&Reviews NewsandComment Editorial | 31March2022 Materialscomealive Thedisseminationofsyntheticbiologyintomaterialsscienceiscreatinganevolvingclassoffunctional,engineeredlivingmaterialsthatcangrow,senseandadaptsimilartobiologicalorganisms. NatureMaterials21,379 News&Views | 31March2022 Livingbuildingblocks Aprototypicalbiocompositeblockcomprisingablendofbacteria,fungiandfeedstockcanbeassembledintohuman-sized,livingstructureswithself-healingandenvironmentalsensingcapabilities. KwokSoonWun,InYoungHwang & MatthewWookChang NatureMaterials21,382-383 Correspondence | 29March2022 Makingspaceforyoungspeakers TaeSeokMoon NatureChemicalBiology18,353 News&Views | 28March2022 Antibodiesasprogrammable,bipedalwalkers Stochasticmodelingofantibodybindingdynamicsonpatternedantigensubstratessuggeststheseparationdistancebetweenadjacentantigenscouldbeacontrolmechanismforthedirectedbipedalmigrationofboundantibodies. NatureComputationalScience,1-2 News&Views | 21March2022 Giveandtakeintheexometabolome Metabolicchangesinauxotrophsenrichthemicrobialcommunityexometabolomeandincreasedrugresistance. KevinR.Stindt & MeganN.McClean NatureMicrobiology7,484-485 News&Views | 15March2022 Definingcancergrowthbeyondthemitoticindex Tumourgrowthinvolvesanomaliesincellcyclegenesandemergentphenotypes,butthetumourproliferationrate(ormitoticindex)isdefinedbyjustonemarker,Ki-67.Astudynowintegratesexpressionpatternsofseveralmarkerstogeneratespatio-temporalmapsofcellproliferationincancertissues. ChandanKumar-Sinha & ArulM.Chinnaiyan NatureCellBiology24,285-287 AllNews&Comment Search Searcharticlesbysubject,keywordorauthor Showresultsfrom Alljournals Search Advancedsearch Quicklinks Explorearticlesbysubject Findajob Guidetoauthors Editorialpolicies